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Manuscript Highlights Therapeutic Potential of BP1003 in Variety of Cancers
Marks Company’s Twenty-Second Peer-Reviewed Publication in Support of its DNAbilize®Technology
HOUSTON, Sept. 16, 2024 (GLOBE NEWSWIRE) -- Bio-Path Holdings, Inc., (NASDAQ:BPTH), a biotechnology company leveraging its proprietary DNAbilize® liposomal delivery and antisense technology to develop a portfolio of targeted nucleic acid cancer drugs, today announced a publication highlighting the therapeutic potential of BP1003 in a variety of cancer types in the peer-reviewed journal, Biomedicines.
The article, titled “BP1003 Decreases STAT3 Expression and Its Pro-Tumorigenic Functions in Solid Tumors and the Tumor Microenvironment,” describes the broad anti-tumor effect of BP1003 in numerous preclinical solid tumor models including breast, ovarian, and pancreatic cancer. BP1003 is a neutral liposome incorporated with a nuclease resistant P-ethoxy antisense oligodeoxynucleotide targeting the STAT3 mRNA and its unique design enhances stability, cellular uptake, and target affinity.
The article was authored by Maria Gagliardi, Ph.D., Senior Research Scientist, Michael Roberts, Director of Manufacturing Planning & Engineering, and Ana Tari Ashizawa, Ph.D., Senior Vice President of Research, Development and Clinical Design at Bio-Path Holdings. The article’s co-authors included investigators from Thomas Jefferson University and University of Texas MD Anderson Cancer Center.
“Overexpression and aberrant activation of STAT3 contributes to tumorigenesis, drug resistance, and tumor-immune evasion, making it a probable cancer therapeutic target. Consequently, we believe BP1003 has the potential to enhance the efficacy of current standard of care chemotherapies in a broad range of difficult to treat cancers,” said Dr. Tari Ashizawa.
About Bio-Path Holdings, Inc.
Bio-Path is a biotechnology company developing DNAbilize®, a novel technology that has yielded a pipeline of RNAi nanoparticle drugs that can be administered with a simple intravenous infusion. Bio-Path’s lead product candidate, prexigebersen (BP1001, targeting the Grb2 protein), is in a Phase 2 study for blood cancers, and BP1001-A, a drug product modification of prexigebersen, is in a Phase 1/1b study for solid tumors. The Company’s second product, BP1002, which targets the Bcl-2 protein, is being evaluated for the treatment of blood cancers and solid tumors, including lymphoma and acute myeloid leukemia. In addition, an IND application is expected to be filed for BP1003, a novel liposome-incorporated STAT3 antisense oligodeoxynucleotide developed by Bio-Path as a specific inhibitor of STAT3.
For more information, please visit the Company's website at http://www.biopathholdings.com.
Forward-Looking Statements
This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws. These statements are based on management's current expectations and accordingly are subject to uncertainty and changes in circumstances. Any express or implied statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Any statements that are not historical facts contained in this release are forward-looking statements that involve risks and uncertainties, including Bio-Path’s ability to raise needed additional capital on a timely basis in order for it to continue its operations, have success in the clinical development of its technologies, the timing of enrollment and release of data in such clinical studies, the accuracy of such data, limited patient populations of early stage clinical studies and the possibility that results from later stage clinical trials with much larger patient populations may not be consistent with earlier stage clinical trials, the maintenance of intellectual property rights, that patents relating to existing or future patent applications will be issued or that any issued patents will provide meaningful protection of our drug candidates, the impact, risks and uncertainties related to global pandemics, including the COVID-19 pandemic, and actions taken by governmental authorities or others in connection therewith, and such other risks which are identified in Bio-Path's most recent Annual Report on Form 10-K, in any subsequent quarterly reports on Form 10-Q and in other reports that Bio-Path files with the Securities and Exchange Commission from time to time. These documents are available on request from Bio-Path Holdings or at www.sec.gov. Bio-Path disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
Contact Information:
Investors
Will O’Connor Stern Investor Relations, Inc.212-362-1200will@sternir.com
Doug Morris Investor Relations Bio-Path Holdings, Inc. 832-742-1369
Dallas, Texas--(Newsfile Corp. - September 4, 2024) - Bio-Path Holdings, Inc. (NASDAQ: BPTH): Stonegate Capital Partners Updates Coverage on Bio-Path Holdings, Inc. (NASDAQ: BPTH) for Q2 2024.
To view the full announcement, including downloadable images, bios, and more, click here (https://api.newsfilecorp.com/redirect/R7NBGhxeVJ).
(https://api.newsfilecorp.com/redirect/W0zP5IAk8B)
Click image above to view full announcement.
About Stonegate
Stonegate Capital Partners is a leading capital markets advisory firm providing investor relations, equity research, and institutional investor outreach services for public companies. Our affiliate, Stonegate Capital Markets (member FINRA) provides a full spectrum of investment banking services for public and private companies.
Contacts:
Stonegate Capital Partners
(214) 987-4121 info@stonegateinc.com
Source: Stonegate, Inc. (https://api.newsfilecorp.com/redirect/q8zmouW0Lo)
To view the source version of this press release, please visit https://www.newsfilecorp.com/release/222180
HOUSTON, Sept. 03, 2024 (GLOBE NEWSWIRE) -- Bio-Path Holdings, Inc., (NASDAQ:BPTH), a biotechnology company leveraging its proprietary DNAbilize® liposomal delivery and antisense technology to develop a portfolio of targeted nucleic acid cancer drugs, today announced that Peter Nielsen, Chief Executive Officer, will participate in a pre-recorded presentation at the H.C. Wainwright 26th Annual Global Investment Conference made available on Monday, September 9, 2024 at 7:00 a.m. ET.
An audio webcast of the presentation will be available here and on the Investor Relations section of Bio-Path’s website, where it will be archived for approximately 90 days.
About Bio-Path Holdings, Inc.
Bio-Path is a biotechnology company developing DNAbilize®, a novel technology that has yielded a pipeline of RNAi nanoparticle drugs that can be administered with a simple intravenous infusion. Bio-Path’s lead product candidate, prexigebersen (BP1001, targeting the Grb2 protein), is in a Phase 2 study for blood cancers, and BP1001-A, a drug product modification of prexigebersen, is in a Phase 1/1b study for solid tumors. The Company’s second product, BP1002, which targets the Bcl-2 protein, is being evaluated for the treatment of blood cancers and solid tumors, including lymphoma and acute myeloid leukemia. In addition, an IND application is expected to be filed for BP1003, a novel liposome-incorporated STAT3 antisense oligodeoxynucleotide developed by Bio-Path as a specific inhibitor of STAT3.
For more information, please visit the Company's website at http://www.biopathholdings.com.
Forward-Looking Statements
This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws. These statements are based on management's current expectations and accordingly are subject to uncertainty and changes in circumstances. Any express or implied statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Any statements that are not historical facts contained in this release are forward-looking statements that involve risks and uncertainties, including Bio-Path’s ability to raise needed additional capital on a timely basis in order for it to continue its operations, have success in the clinical development of its technologies, the timing of enrollment and release of data in such clinical studies, the accuracy of such data, limited patient populations of early stage clinical studies and the possibility that results from later stage clinical trials with much larger patient populations may not be consistent with earlier stage clinical trials, the maintenance of intellectual property rights, that patents relating to existing or future patent applications will be issued or that any issued patents will provide meaningful protection of our drug candidates, the impact, risks and uncertainties related to global pandemics, including the COVID-19 pandemic, and actions taken by governmental authorities or others in connection therewith, and such other risks which are identified in Bio-Path's most recent Annual Report on Form 10-K, in any subsequent quarterly reports on Form 10-Q and in other reports that Bio-Path files with the Securities and Exchange Commission from time to time. These documents are available on request from Bio-Path Holdings or at www.sec.gov. Bio-Path disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
Contact Information: Investors
Will O’Connor Stern Investor Relations, Inc.212-362-1200will@sternir.com
Doug Morris Investor Relations Bio-Path Holdings, Inc. 832-742-1369
Bio-Path Holdings, Inc. shares closed slightly higher Wednesday after the company provided an update from its ongoing Phase 1/1b clinical trial of BP1001-A in solid tumor patients and reported continued patient progress from its ongoing Phase 2 triple combination study of prexigebersen in Acute Myeloid Leukemia.
The Details: Bio-Path said the first patient treated with the higher dose in its Phase 1/1b study of BP1001-A has shown tumor regression and stable disease.
“These positive responses mark a significant milestone for Bio-Path as they suggest our DNAbilize platform technology has the potential to produce multiple drug candidates capable of target-specific protein inhibition for over-expressed, disease-causing gene products,” said Peter H. Nielsen, CEO of Bio-Path.
Read Next: Microchip Technology Stock Dips After Cybersecurity Incident
What Else: Bio-Path reported its second-quarter financial results last week and beat analyst expectations with GAAP losses of $1.16 per share.
Research and development expenses decreased to $1.9 million primarily due to decreased manufacturing expenses and partially offset by an increase in expenses related to its clinical trial for BP1002 in lymphoma due to increased patient enrollment in 2024.
Bio-Path shares are moving lower in Wednesday’s after-hours session.
BPTH Stock Prediction 2024: Equity research analysts on and off Wall Street typically use earnings growth and fundamental research as a form of valuation and forecasting. But many in trading turn to technical analysis as a way to form predictive models for share price trajectory.
Some investors look to trends to help forecast where they believe a stock could trade at a certain point in the future. Looking at Bio-Path Holdings, an investor could make an assessment about a stock's long-term prospects using a moving average and trend line.
If they believe a stock will remain above the moving average, which many believe is a bullish signal, they can extrapolate that trend into the future using a trend line. For Bio-Path, the 200-day moving average sits at $5.55, according to Benzinga Pro, which is above the current price of $1.40. For more on charts and trend lines, see a description here.
Traders believe that when a stock is above its moving average, it is a generally bullish signal, and when it crosses below, it is a more negative signal. Investors could use trend lines to make an educated guess about where a stock could trade at a later date if conditions remain stable.
BPTH Price Action: According to Benzinga Pro, Bio-Path Holdings shares are down 6.7% after-hours at $1.40 at the time of publication Wednesday.
Photo: Shutterstock
© 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
US equity futures were cautiously higher before Wednesday's opening bell as traders looked ahead to
minutes from the last Federal Reserve meeting for clues about future monetary policy.
The Dow Jones Industrial Average futures gained 0.2%, S&P 500 futures increased 0.3%, and Nasdaq futures were up 0.2%.
Oil prices were higher, with front-month global benchmark North Sea Brent crude up 0.3% at $77.44 per barrel and US West Texas Intermediate crude up 0.3% at $73.39 per barrel.
The policy-setting Federal Open Market Committee is scheduled to release the minutes from its July 30-31 meeting at 2 pm ET. During the last meeting, the FOMC left the target range for the federal funds rate at 5.25% to 5.50%.
Fed Chair Jerome Powell and other central bank officials will gather this week for the annual economic symposium in Jackson Hole, Wyoming.
In other world markets, Japan's Nikkei closed 0.3% lower, Hong Kong's Hang Seng ended 0.7% lower, and China's Shanghai Composite finished 0.4% lower. Meanwhile, the UK's FTSE 100 gained 0.2%, and Germany's DAX index rose 0.6% in Europe's early afternoon session.
In equities, shares of Target Corporation were 15% higher pre-bell after the retailer posted higher fiscal Q2 adjusted earnings and revenue and lifted its fiscal 2024 guidance. Bio-Path Holdings shares rose 22% after the company reported that a patient in its phase 1/1b trial of a solid tumor drug candidate experienced tumor reduction.
On the losing side, Macy's shares fell 9% after reporting a drop in its fiscal Q4 revenue while cutting its fiscal 2024 revenue guidance. Aadi Bioscience shares retreated 15% after the company unveiled planned job cuts and a halt to its tumor treatment trial.
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