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European equities traded in the US as American depositary receipts were trending modestly lower late Tuesday morning, declining 0.16% to 1,445.76 on the S&P Europe Select ADR Index.
From continental Europe, the gainers were led by biopharmaceutical company Genfit and pharmaceutical company Ascendis Pharma , which rose 6.8% and 5.7% respectively. They were followed by internet advertising firm Criteo and biotech firm BioNTech , which increased 2.3% and 0.5% respectively.
The decliners from continental Europe were led by furniture maker Natuzzi and medical device maker EDAP TMS , which fell 6.7% and 3.3% respectively. They were followed by biotech firm Evaxion Biotech and biopharmaceutical company DBV Technologies , which lost 2.8% and 1.5% respectively.
From the UK and Ireland, the gainers were led by biopharmaceutical companies Biodexa Pharmaceuticals and Akari Therapeutics , which were up 2% and 3.6% respectively. They were followed by pharmaceutical company Silence Therapeutics and insurance company Prudential , which increased 3.4% and 1.3% respectively.
The decliners from the UK and Ireland were led by biopharmaceutical company NuCana , which tumbled 31.4%, followed by tobacco company British American Tobacco , which was down 2.7%. Pharmaceutical company GSK and medical device maker Smith & Nephew dropped 1.7% and 1.2% respectively.
Shares of NuCana plc NCNA skyrocketed 150.8% on Monday after the announcement of encouraging final data from the mid-stage study of its investigational candidate, NUC-7738, in combination with Merck’s MRK blockbuster oncology drug, Keytruda (pembrolizumab), to treat metastatic melanoma. The melanoma patient population included those who were refractory to or had relapsed on prior PD-1 inhibitor therapy.
The results were presented at the ESMO Congress held on Sept. 14, 2024, in Spain.
NCNA Combo Therapy Shows Superior Efficacy in Melanoma Study
Per the data readout from the phase II NuTide:701 study, out of the 12 patients treated with the NUC-7738/Meck’s Keytruda combo regimen, nine (75%) achieved disease control, including two patients who achieved partial responses.
A patient who had previously undergone two rounds of PD-1 inhibitor therapy and experienced disease progression within two months after treatment with Bristol Myers’ BMY Yervoy (ipilimumab) and Opdivo (nivolumab), achieved a 55% reduction in tumor size. Additionally, seven out of the 12 patients had a progression-free survival exceeding five months, which is unusually long for this group. Per NuCana, the median progression-free survival duration with the standard-of-care treatment for PD-1 inhibitor refractory and resistant melanoma patients is 2-3 months.
In the NuTide:701 study, the combination of NUC-7738 and Meck’s Keytruda also demonstrated a favorable safety profile.
NUC-7738 is a novel anti-cancer agent that disrupts RNA polyadenylation. Its unique mechanism of action allows the candidate to sensitize PD-1-resistant tumors to rechallenge with PD-1 inhibitors. Per the company, the data presented from tumor biopsies obtained before and after NUC-7738-based treatment demonstrated increases in genes related to antigen presentation and T-cell activation, which supports the hypothesis.
Year to date, shares of NuCana have lost 13.9% against the industry’s 0.5% growth.
Bristol Myer’s immunotherapy drug, Opdivo, in combination with Yervoy, is indicated for the treatment of adult and pediatric patients of 12 years and older with unresectable or metastatic melanoma. Both drugs are individually approved for the melanoma indication. Bristol Myer is also currently conducting studies to further expand the combo’s label. Bristol Myer’s Opdivo is approved both as a monotherapy and in combination with Yervoy to treat several other cancer indications in many countries, including the United States and the EU.
Like Bristol Myers’ Opdivo, Merck’s Keytruda is also an anti-PD-1 therapy. It is currently marketed as the standard of care in the frontline treatment of metastatic non-small cell lung cancer patients. Merck’s Keytruda is approved for several types of cancer, accounting alone for 47% of the company’s pharmaceutical sales in 2023. Keytruda is continuously growing and expanding into new indications and markets globally, bolstering Merck’s position in the oncology market.
NuCana’s Future Plans for NUC-7738 Clinical Development
Based on additional data on NUC-7738 obtained in other tumor types, NuCana believes that the unique mechanism of action of the candidate is not restricted to melanoma and that NUC-7738 could potentially sensitize other PD-1 inhibitor-resistant tumor types.
The company expects to share further development plans for NUC-7738 soon.
NuCana PLC Sponsored ADR Price and Consensus
NuCana PLC Sponsored ADR price-consensus-chart | NuCana PLC Sponsored ADR Quote
NuCana’s Other Pipeline Developmental Programs
Apart from NUC-7738, NuCana’s clinical pipeline has another investigational candidate, NUC-3373, which is currently being evaluated in combination with other agents in three separate early to mid-stage studies to treat colorectal cancer, lung cancer and advanced solid tumors.
Data readouts from all three studies are expected by the end of 2024.
Zacks Rank & Stock to Consider
NuCana currently carries a Zacks Rank #3 (Hold).
A better-ranked stock in the biotech sector is Illumina, Inc. ILMN, sporting a Zacks Rank #1 (Strong Buy) at present. You can see the complete list of today’s Zacks #1 Rank stocks here.
In the past 60 days, estimates for Illumina’s 2024 earnings per share have moved up from $1.84 to $3.62. The consensus estimate for 2025 earnings has improved from $3.22 to $4.43. Year to date, shares of ILMN have lost 7%.
ILMN’s earnings beat estimates in each of the trailing four quarters, the average surprise being 463.46%.
Zacks Investment Research
Shares of Zentalis Pharmaceuticals ZNTL gained 13.6% on Monday after it announced that the FDA has lifted the partial clinical hold previously imposed on three studies of the company’s lead product candidate, azenosertib, for three different cancer indications. The decision was based on the regulatory body’s review of Zentalis’ complete response package, which included a comprehensive safety assessment of the azenosertib program.
Zentalis’ azenosertib, a potentially first-in-class oral WEE1 inhibitor, is currently being studied as a monotherapy and in combination with other therapies for treating different types of cancer indications, including solid tumors and ovarian cancer.
Per Zentalis, the FDA has given the green light to resume enrollment in all ongoing azenosertib clinical studies with no changes in the clinical development plan. The company is gearing up to resume study activities across the azenosertib development program at the earliest.
Year to date, shares of Zentalis have plunged 75.7% against the industry’s 0.5% growth.
Developmental Setbacks Faced by ZNTL for Azenosertib
In June 2024, the FDA placed a partial clinical hold on the following azenosertib studies — the phase I ZN-c3-001 dose-escalation for solid tumors, the phase II ZN-c3-005 DENALI study for platinum-resistant ovarian cancer (PROC) and the phase II ZN-c3-004 TETON study for uterine serous carcinoma.
This action was taken by the regulatory body after two patients in the DENALI study died due to presumed sepsis. This resulted in a huge dip in Zentalis’ share price back then.
In its second-quarter earnings release, Zentalis announced that it has discontinued the development of the combination of its BCL-2 inhibitor, ZN-d5, with azenosertib due to unsatisfactory efficacy data. The combo therapy was evaluated in a phase I study for the treatment of relapsed or refractory acute myeloid leukemia.
ZNTL’s Future Clinical Development Plan for Azenosertib
ZNTL has already completed enrollment in cohort 1b of the DENALI study. Overall efficacy and safety data from the same is expected to be announced later in 2024. Zentalis also plans to present data from the ZN-c3-001 and the MAMMOTH studies later in the ongoing year.
The phase I/II MAMMOTH (ZN-c3-006) study is evaluating azenosertib in combination with GSK’s GSK PARP inhibitor Zejula (niraparib) and azenosertib as monotherapy for treating PROC.
The study is being conducted in partnership with GSK.
GSK’s Zejula is already approved for ovarian cancer and is currently being studied for additional ovarian cancer stages as well as non-small cell lung cancer and endometrial cancer.
Per the latest press release, Zentalis is scheduled to present azenosertib monotherapy data and provide additional updates on the azenosertib clinical development program and other data presentation timelines at an upcoming medical conference.
Zentalis Pharmaceuticals, Inc. Price and Consensus
Zentalis Pharmaceuticals, Inc. price-consensus-chart | Zentalis Pharmaceuticals, Inc. Quote
Zacks Rank & Stocks to Consider
Zentalis currently carries a Zacks Rank #3 (Hold).
Some better-ranked stocks in the biotech sector are Illumina, Inc. ILMN and Fulcrum Therapeutics, Inc. FULC, each sporting a Zacks Rank #1 (Strong Buy) at present. You can see the complete list of today’s Zacks #1 Rank stocks here.
In the past 60 days, estimates for Illumina’s 2024 earnings per share have moved up from $1.84 to $3.62. The consensus estimate for 2025 earnings has improved from $3.22 to $4.43. Year to date, shares of ILMN have lost 7%.
ILMN’s earnings beat estimates in each of the trailing four quarters, the average surprise being 463.46%.
In the past 60 days, estimates for Fulcrum Therapeutics’ 2024 loss per share have narrowed from $1.24 to 33 cents. The consensus estimate for 2025 loss per share has narrowed from $1.71 to $1.14. Year to date, shares of FULC have plunged 52.9%.
FULC’s earnings beat estimates in each of the trailing four quarters, the average surprise being 393.18%.
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