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Biotech giant Regeneron Pharmaceuticals, Inc. REGN is slated to report fourth-quarter and full-year 2024 results on Feb. 4, 2025.
The Zacks Consensus Estimate for fourth-quarter revenues is pegged at $3.78 billion, while the same for earnings is pinned at $11.60 per share.
Find the latest EPS estimates and surprises on Zacks Earnings Calendar.
Regeneron Pharmaceuticals, Inc. Price, Consensus and EPS Surprise
Regeneron Pharmaceuticals, Inc. price-consensus-eps-surprise-chart | Regeneron Pharmaceuticals, Inc. Quote
Dupixent Fuels Growth for REGN
A significant chunk of Regeneron’s revenues comes from the sale of its lead drug, Eylea, which is approved for various ophthalmology indications (neovascular age-related macular degeneration, diabetic macular edema [DME] and macular edema, among others). Eylea was developed in collaboration with pharma giant Bayer.
While Regeneron records net product sales of Eylea in the United States, Bayer does the same outside the United States. The company also records its share of profits/losses in connection with Eylea sales outside the country.
Eylea’s sales have been under pressure in the recent quarters due to competition from Vabysmo.
To counter the decline in Eylea sales, Regeneron developed a higher dose of the drug. The initial uptake of Eylea HD is encouraging as Eylea patients transition to the higher dose.
Earlier this month, Regeneron provided business and pipeline updates at the 43rd Annual J.P. Morgan Healthcare Conference. Regeneron reported that, on a combined basis, Eylea 2 mg and Eylea HD maintained their leadership position in the anti-VEGF category leader in 2024 in the United States.
On a preliminary basis, Eylea and Eylea HD recorded $6 billion in sales in 2024 in the United States. Sales for the fourth quarter totaled $1.5 billion in the United States.
On a standalone basis, Eylea sales totaled $1.19 billion in the United States in the fourth quarter of 2024. Eylead HD’s net product sales were $305 million for the quarter in the United States.
The total Eylea franchise sales in the United States for the fourth quarter were favorably impacted by approximately $85 million as a result of higher wholesaler inventory levels for Eylea, partially offset by lower wholesaler inventory levels for Eylea HD.
Apart from Eylea, profits from asthma drug Dupixent’s sales are a primary growth driver for REGN. Regeneron has a collaboration agreement with Sanofi for drugs like Dupixent and Kevzara. While Sanofi records sales, Regeneron registers its share of profits/losses in connection with the global sales of the aforementioned drugs.
Sanofi recorded Dupixent sales of €3.46 billion for the fourth quarter, up 16%, driven by continued strong prescription trends in atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis, eosinophilic esophagitis and prurigo nodularis. Hence, Regeneron has likely earned incremental profits from Dupixent in the to-be-reported quarter.
However, sales growth was affected by fewer business days in the fourth quarter compared to prior periods and a year-end gross-to-net adjustment.
Meanwhile, Regeneron is also looking to diversify its revenue base to reduce its dependence on Eylea for top-line growth and build an oncology franchise, which currently comprises Libtayo.
Growth in Libtayo’s sales has also boosted the top line in recent quarters. Libtayo sales are being driven by growth in demand for non-melanoma skin indications, coupled with increased utilization in both monotherapy and chemotherapy combination settings in lung cancer. The Zacks Consensus Estimate for Libtayo’s sales is currently pegged at $339 million.
REGN is currently working to expand Libatyo’s label, in combination with other compounds, in additional indications.
REGN’s oncology franchise received a boost with the European Commission's approval of odronextamab for treating adult patients with relapsed or refractory (R/R) follicular lymphoma (FL) or R/R diffuse large B-cell lymphoma after two or more lines of systemic therapy. The drug has been approved under the brand name Ordspono.
Other Updates From REGN
Investors will also look for key pipeline updates from Regeneron apart from the top and bottom-line numbers.
REGN filed an application with the FDA for the use of the Eylea HD pre-filled syringe (PFS). A potential approval and launch are expected by mid-2025.
An application to expand Dupixent’s label to include chronic spontaneous urticaria is under review in the United States, with a target action date of April 18, 2025.
What Our Model Predicts for REGN
Our proven model predicts an earnings beat for Regeneron this time around. The combination of a positive Earnings ESP and a Zacks Rank #1 (Strong Buy), 2 (Buy) or 3 (Hold) increases the odds of an earnings beat. This is the case here, as you will see below.
Earnings ESP: Earnings ESP for REGN is +0.22%, as the Zacks Consensus Estimate is currently pinned at $11.60 per share and the Most Accurate Estimate is pegged at $11.63 per share. You can uncover the best stocks to buy or sell before they're reported with our Earnings ESP Filter.
Zacks Rank: The company currently carries a Zacks Rank #3 (Hold).
REGN’s Earnings Surprise History
The company’s earnings beat estimates in three of the trailing four quarters and missed the same in the other one, delivering an average surprise of 5.69%. In the last reported quarter, REGN beat on earnings by 6.04%.
REGN’s Share Price Performance
Regeneron’s shares have lost 28.8% in the past year compared with the industry’s decline of 11.3%.
Other Stocks to Consider
Here are some other biotech stocks that you may want to consider, as our model shows that these too have the right combination of elements to post an earnings beat this reporting cycle.
Sarepta Therapeutics SRPT has an Earnings ESP of +18.55% and a Zacks Rank #2 at present. You can see the complete list of today’s Zacks #1 Rank stocks here.
SRPT beat on earnings in each of the trailing four quarters, the average surprise being 981.21%.
Rocket Pharmaceuticals RCKT has an Earnings ESP of +1.58% and a Zacks Rank #2.
RCKT’s earnings outpaced estimates in three of the trailing four quarters and matched the same in one, delivering an average surprise of 8.33%.
Amgen AMGN has an Earnings ESP of +3.15% and a Zacks Rank #3 at present.
AMGN beat on earnings in each of the trailing four quarters, delivering an average surprise of 4.10%. Amgen is scheduled to release fourth-quarter results on Feb. 4, 2025.
Zacks Investment Research
Regeneron Pharmaceuticals has an average rating of overweight and mean price target of $984, according to analysts polled by FactSet.
The upcoming report from Regeneron (REGN) is expected to reveal quarterly earnings of $11.60 per share, indicating a decline of 2.2% compared to the year-ago period. Analysts forecast revenues of $3.78 billion, representing an increase of 10.1% year over year.
The consensus EPS estimate for the quarter has undergone an upward revision of 0.8% in the past 30 days, bringing it to its present level. This represents how the covering analysts, as a whole, have reassessed their initial estimates during this timeframe.
Ahead of a company's earnings disclosure, it is crucial to give due consideration to changes in earnings estimates. These revisions serve as a noteworthy factor in predicting potential investor reactions to the stock. Numerous empirical studies consistently demonstrate a strong relationship between trends in earnings estimate revision and the short-term price performance of a stock.
While investors typically rely on consensus earnings and revenue estimates to gauge how the business may have fared during the quarter, examining analysts' projections for some of the company's key metrics often helps gain a deeper insight.
With that in mind, let's delve into the average projections of some Regeneron metrics that are commonly tracked and projected by analysts on Wall Street.
It is projected by analysts that the 'Revenues- Other Revenue' will reach $167.10 million. The estimate suggests a change of -21.4% year over year.
The consensus among analysts is that 'Revenues- Net product sales' will reach $1.94 billion. The estimate indicates a change of +4.6% from the prior-year quarter.
Based on the collective assessment of analysts, 'Revenues- Collaboration' should arrive at $1.69 billion. The estimate indicates a year-over-year change of +23.2%.
The combined assessment of analysts suggests that 'Revenues- Libtayo- Total' will likely reach $338.92 million. The estimate indicates a change of +39% from the prior-year quarter.
The consensus estimate for 'Revenues- Eylea (Aflibercept)- US' stands at $1.50 billion. The estimate points to a change of +12.1% from the year-ago quarter.
The collective assessment of analysts points to an estimated 'Revenues- Praluent (alirocumab)- US' of $37.32 million. The estimate indicates a change of -39.1% from the prior-year quarter.
Analysts forecast 'Revenues- Evkeeza- US' to reach $45.64 million. The estimate points to a change of +90.2% from the year-ago quarter.
Analysts expect 'Revenues- Libtayo- ROW' to come in at $121.81 million. The estimate suggests a change of +36.9% year over year.
According to the collective judgment of analysts, 'Revenues- Libtayo- US' should come in at $206.58 million. The estimate points to a change of +33.5% from the year-ago quarter.
Analysts' assessment points toward 'Revenues- Dupixent (dupilumab)- US' reaching $3.00 billion. The estimate indicates a year-over-year change of +20.6%.
The average prediction of analysts places 'Revenues- Kevzara (sarilumab)- ROW' at $46.65 million. The estimate indicates a change of +1.4% from the prior-year quarter.
Analysts predict that the 'Revenues- Kevzara (sarilumab)- US' will reach $69.95 million. The estimate indicates a year-over-year change of +5.7%.
View all Key Company Metrics for Regeneron here>>>
Shares of Regeneron have experienced a change of -4.5% in the past month compared to the +2.9% move of the Zacks S&P 500 composite. With a Zacks Rank #3 (Hold), REGN is expected to mirror the overall market performance in the near future. You can see the complete list of today's Zacks Rank #1 (Strong Buy) stocks here
Zacks Investment Research
The fourth-quarter 2024 earnings cycle is here, with quite a few healthcare companies having reported results. Early reports indicate several key growth drivers at play, including increased patient volumes, utilization, admissions, patient days and rate hikes, as well as growing demand for commercial healthcare plans and technology-enabled offerings. However, rising medical costs due to increased utilization and occupancy have partly offset the positives.
Based on our exclusive research and unique market insight, we present four stocks — Amgen Inc. AMGN, Cencora, Inc. COR, Humana Inc. HUM and Ardent Health Partners, Inc. ARDT — which are set to beat earnings estimates this earnings season.
See the Zacks Earnings Calendar to stay ahead of market-making news.
Q4 Expectations
Before delving into the specifics of what could have impacted fourth-quarter performance, let's examine the sector forecasts.
The healthcare space is a part of the broader Zacks Medical sector (one of the 16 broad Zacks sectors within the Zacks Industry). According to the latest Earnings Trends report dated Jan. 29, the medical sector is projected to experience 12.5% growth in earnings for the fourth quarter, while revenues are anticipated to rise by 8.6%.
Factors at Play for Healthcare Stocks in Q4
The healthcare sector is vast and complex, covering hospitals, medical services, nursing homes, health insurance, medical devices, pharmaceuticals, and outpatient and home healthcare. A growing aging population and rising demand for healthcare products and services continue to drive sales for industry players.
However, investments in technology and innovation have likely pressured profit margins in the short term. Higher salaries and benefits have also increased overall costs for healthcare companies. Additionally, some HMO companies are expected to have seen a decline in Medicaid and Medicare memberships due to redeterminations.
The patient volumes likely rose in the fourth quarter, driven by more visits and surgeries. Increased revenue per admission should have further boosted top-line growth. The continued resumption of elective procedures, particularly among seniors, also contributed to higher patient volumes. However, this surge in utilization may have led to higher medical costs, potentially squeezing profit margins.
To offset rising medical cost trends, some companies likely implemented premium rate hikes, providing some financial relief. Health insurers may have also benefited from new product offerings, technological advancements, premium growth and increased investment income. Meanwhile, the demand for affordable healthcare plans may have driven higher membership in the commercial market.
On the positive side, technological innovations continue to reshape the healthcare industry. AI and automation are improving clinical workflows, enhancing diagnostics and reducing unnecessary costs. These advancements have likely helped hospitals optimize services, shorten patient wait times, enhance the overall patient experienceand lower treatment expenses.
How to Identify Potential Outperformers?
Identifying healthcare stocks with the potential for an earnings beat can be challenging amid the crowded investment landscape. However, our proprietary methodology simplifies this task, offering insights into potential outperformers. With our unique research and deep market analysis, we've identified the healthcare stocks using the Zacks Stock Screener.
These stocks have the ideal combination of two ingredients — a positive Earnings ESP and a Zacks Rank #1 (Strong Buy), 2 (Buy) or 3 (Hold) — to surpass expectations. Our research shows that for stocks with this combination, the chances of an earnings beat are as high as 70%. You can uncover the best stocks to buy or sell before they are reported with our Earnings ESP Filter.
Potential Outperformers
One might start with Cencora, which is one of the major pharmaceutical services companies. Headquartered in Conshohocken, PA, the company’s December-quarter earnings are expected to have benefited from increased sales of GLP-1 drugs and specialty products and higher operating income from the global specialty logistics business. Higher days payable and growth in the U.S. Healthcare Solutions business are likely to have positioned the company for an earnings beat this time around.
The Zacks Consensus Estimate for Cencora’s fiscal first-quarter earnings is pegged at $3.50 per share, which remained stable over the past week. It beat earnings estimates in all the past four quarters, with an average of 7%. COR has an Earnings ESP of +0.63% and a Zacks Rank #2. You can see the complete list of today’s Zacks #1 Rank stocks here.
Cencora, Inc. Price and EPS Surprise
Cencora, Inc. price-eps-surprise | Cencora, Inc. Quote
You may also watch Thousand Oaks, CA-based Amgen, one of the biggest biotech companies in the world, which has an Earnings ESP of +3.15% and a Zacks Rank #3.
Its fourth-quarter earnings are likely to have gained from growing product sales in Prolia, Repatha, Kyprolis, Xgeva, Vectibix and others. Growth in rare disease drugs, mostly Horizon’s products, will likely boost its results. The Zacks Consensus Estimate for Amgen’s fourth-quarter earnings indicates a 6.4% improvement from a year ago. The estimate remained stable over the past week. It beat earnings estimates in each of the past four quarters, the average surprise being 4.1%.
Amgen Inc. Price and EPS Surprise
Amgen Inc. price-eps-surprise | Amgen Inc. Quote
Louisville, KY-based Humana also deserves mention. It is a healthcare plan provider witnessing strong premium growth, improving cost management and growing memberships. It has an Earnings ESP of +0.23% and a Zacks Rank #3. The consensus mark for fourth-quarter revenues is pegged at $28.82 billion.
An expanding value-based home care model is expected to benefit HUM’s CenterWell unit. The Zacks Consensus Estimate for Humana’s fourth-quarter earnings remained stable over the past week with no revisions in estimates. It beat earnings estimates thrice in the past four quarters and missed once, the average surprise being 0.2%.
Humana Inc. Price and EPS Surprise
Humana Inc. price-eps-surprise | Humana Inc. Quote
Finally, we have Brentwood, TN-based Ardent Health, which provides healthcare services through a network of hospitals and clinics. Rising adjusted admissions, higher revenue per admission and patient days are likely to have positioned ARDT for better-than-expected fourth-quarter earnings.
The Zacks Consensus Estimate for Ardent Health’s bottom line for the to-be-reported is pegged at 45 cents per share, which remained stable over the past week. The consensus mark for revenues is pegged at $1.49 billion. ARDT has an Earnings ESP of +0.74% and a Zacks Rank #3. It beat earnings estimates once and missed one time in the past two quarters.
Ardent Health Partners, Inc. Price and EPS Surprise
Ardent Health Partners, Inc. price-eps-surprise | Ardent Health Partners, Inc. Quote
Zacks Investment Research
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